In American literature what is the significance of Adventures of Huckleberry Finn by Mark Twain?

In American literature what is the significance of Adventures of Huckleberry Finn by Mark Twain?

The Adventures of Tom Sawyer and, especially, its sequence Adventures of Huckleberry Finn proved themselves to be the milestone in American literature, and thus firmly established Twain s position in the literary world.
The childhood of Tom Sawyer and Huck Finn in the Mississippi is a record of a vanished way of life in the pre-Civil War Mississippi valley and it has moved millions of people of different ages and conditions all over the world.
"Huckleberry Finn" marks the climax of Twain's literary creativity. Hemingway once described the novel the one book forms which “a modern American literature comes”. (p482)

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